Hilton Head Pharmacy Guide: Every Island Pharmacy
Every pharmacy on Hilton Head Island by area, with pharmacy hours, Sunday and late-night options, delivery and prescription transfers.
Hilton Head Pharmacy: Free Delivery on the Island
5 Park Ln, Hilton Head Island, SC 29928
Owned by three local pharmacists. Free delivery anywhere on the island, prescription transfers, vaccines and compounding. Mon to Fri 9 to 6, Sat 9 to 2.
Hilton Head Pharmacy is the island’s newest independent, on Park Lane off Pope Avenue, owned by three local pharmacists. It delivers prescriptions free anywhere on Hilton Head, so a guest who left medicine at home can have it brought to the rental the same day, and it handles transfers, vaccines and compounding, including for pets.
Hilton Head Island Pharmacies by Area
The pharmacies on Hilton Head Island run from Pope Avenue to the bridges, and most of them keep shorter hours than the store around them. Each chain has its own page with both stores: CVS and Walgreens.
South End: Sea Pines, Coligny and Shipyard
10 Pope Ave, Hilton Head Island, SC 29928
Drive-thru pharmacy Mon to Fri 9 to 7, Sat 10 to 6, Sun 11 to 5. The store stays open until midnight every day.
11 Palmetto Bay Rd Ste 110, Hilton Head Island, SC 29928
Beside the Publix by Sea Pines Circle. Pharmacy Mon to Sat 10 to 6; the store is open 7 a.m. to midnight.
33 Office Park Road Ste 100, Hilton Head Island, SC 29928
The pharmacy inside the Park Plaza Harris Teeter off Pope Avenue, open seven days.
Mid-Island: Palmetto Dunes and Shelter Cove
42 Shelter Cove Lane, Hilton Head Island, SC 29928
The mid-island pharmacy, with a drive-up window, compounding and medical supplies, inside the island’s biggest supermarket.
North End: Port Royal, Main Street and Hilton Head Plantation
45 Pembroke Dr, Hilton Head Island, SC 29926
The latest pharmacy counter on the island: Mon to Fri 9 to 9, Sat 9 to 7, Sun 11 to 6. The only Publix on the island with a pharmacy.
25 Pembroke Dr, Hilton Head Island, SC 29926
The pharmacy in the Walmart Supercenter by the bridges, open until 7 p.m.
20 Hatton Pl, Hilton Head Island, SC 29926
Near the hospital. Pharmacy Mon to Fri 9 to 6, closed weekends; the store is open 8 a.m. to 9 p.m. daily.
85 Mathews Dr, Hilton Head Island, SC 29926
Pharmacy Mon to Fri 9 to 8, weekends 10 to 6. The store is open 8 a.m. to 10 p.m.
1101 Main St, Hilton Head Island, SC 29926
A local independent with compounding, curbside pickup and medical equipment rentals, from beach wheelchairs to oxygen. Mon to Fri 9 to 7, Sat 9 to 6, Sun 9 to 3.
301 Main Street, Hilton Head Island, SC 29926
The pharmacy inside the north-end Harris Teeter on Main Street. Call the store for the pharmacy.
60 Palmetto Pkwy Ste A, Hilton Head Island, SC 29926
Custom-made prescriptions and supplements, with a small wellness shop. Mon to Fri 9 to 5:30, Sat 9 to 1.
Is There a 24-Hour Pharmacy on Hilton Head?
No. There is no 24-hour pharmacy on Hilton Head Island, and none in Bluffton or Savannah either, whatever older listings say. The latest pharmacy counter on the island is Publix at Festival Centre, open until 9 p.m. on weekdays, then CVS on Mathews Drive, until 8. For over-the-counter medicine late at night, the CVS on Pope Avenue and the Walgreens at Island Crossing keep their stores open until midnight. After that, the only help is the emergency room at Hilton Head Medical Center.
On Sunday, the pharmacies open are both CVS stores, Publix at Festival Centre and Burke’s Main Street Pharmacy, which opens at 9. Neither Walgreens pharmacy opens on Sunday, and Hilton Head Pharmacy and Stephens are closed. Most chain pharmacies also close for half an hour at lunch, around 1:30.
Forgot a Prescription? Transfers on Vacation
To fill a prescription on vacation, call the island pharmacy nearest your rental and give it your home pharmacy’s name and phone number: it will transfer the prescription, usually within a few hours. A CVS or Walgreens customer can refill at the island store of the same chain from the app. For a new prescription after a clinic visit, ask the clinic to send it to the pharmacy that is open latest that day, or to Hilton Head Pharmacy for delivery.
Controlled medicines, such as some pain and ADHD prescriptions, are harder to transfer across state lines, so pack enough for the whole trip. If you feel too unwell to wait for a transfer, the Hilton Head urgent care clinics can examine you and write a new prescription.
Compounding and Medical Equipment
Three island pharmacies make compounded prescriptions: Stephens Compounding Pharmacy, which does nothing else, Burke’s and Hilton Head Pharmacy; the Kroger pharmacy compounds too. For medical equipment, Burke’s rents beach wheelchairs, power and manual wheelchairs, scooters, walkers and hospital beds, and supplies CPAP and oxygen. Our medical equipment rentals list has the companies that deliver to your rental and lets you book a wheelchair or scooter online.
For property managers and owners: list the nearest pharmacy for each property in the welcome book, with its Sunday hours, and point guests who forgot a prescription to Hilton Head Pharmacy’s free island delivery. Guests in the north-end communities have Burke’s, open on Sunday, and the Festival Centre Publix, open latest.
Frequently Asked Questions
Is there a 24-hour pharmacy on Hilton Head Island?
No. No pharmacy on Hilton Head, in Bluffton or in Savannah is open around the clock. The CVS on Pope Avenue and the Walgreens at Island Crossing keep their stores open until midnight for over-the-counter medicine, and the latest pharmacy counter is Publix at Festival Centre, open until 9 p.m. on weekdays. After that, the hospital emergency room is the only option.
Which Hilton Head pharmacies are open on Sunday?
CVS on Pope Avenue (11 to 5) and on Mathews Drive (10 to 6), Publix at Festival Centre (11 to 6) and Burke’s Main Street Pharmacy (9 to 3). Neither Walgreens pharmacy is open on Sunday.
Does any pharmacy on Hilton Head deliver?
Yes. Hilton Head Pharmacy, an independent on Park Lane, delivers free anywhere on the island. CVS offers same-day delivery from both of its stores, and Walgreens delivers for a fee.
How do I get a prescription filled on vacation in Hilton Head?
Call the island pharmacy closest to your rental with your home pharmacy’s name and number, and it will transfer the prescription; allow a few hours. If your home pharmacy is CVS or Walgreens, the island store of the same chain can see the prescription already. Controlled medicines can be harder to transfer, so bring enough for the trip.
What is the best pharmacy in Hilton Head?
For personal service, the island’s independents: Hilton Head Pharmacy (free island delivery), Burke’s Main Street Pharmacy (open Sunday, medical equipment rentals) and Stephens Compounding Pharmacy (custom prescriptions). For late hours, the Pope Avenue CVS store is open until midnight.
Keep exploring
Sea Pines security: the CSA's 24-hour dispatch line, what its deputized officers do, and when to call about alligators, lost items or car trouble.
The Sea Pines ARB approves every exterior change and tree removal. What needs approval, the 6-inch tree rule, fees, meetings and deadlines.
CVS on Hilton Head Island has two stores: Pope Avenue, open to midnight with a MinuteClinic, and Mathews Drive. Store and pharmacy hours and phones.
Walgreens Hilton Head: the Island Crossing store, open to midnight, and Hatton Place. Store and pharmacy hours, Sunday closures and phone numbers.
Local guides like this come standard for Guests of Partner Properties — one small part of what a Partner Property gives every guest.
Book Partner Properties